Chromatography Filtration Solutions for HPLC, UHPLC & LC-MS
High-performance syringe filters and membrane disc filters engineered for reliable, reproducible chromatography results.
- Ultra-clean filtration — minimal extractables
- Stable chromatographic baselines guaranteed
- Protects expensive HPLC columns from particulates
- Compatible with HPLC, UHPLC & LC-MS systems
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Why Filtration Is Critical in Chromatography
Unfiltered or poorly filtered samples cause costly system failures and unreliable analytical data. Here’s what’s at stake:
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Column Blockage & Reduced Lifespan
Particulate matter clogs packed HPLC columns, causing irreversible pressure build-up and expensive column replacement.
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Baseline Noise & Ghost Peaks
Matrix interferences introduce noise and false peaks, invalidating quantitative analysis and requiring repeat runs.
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Pressure Instability & System Errors
Inconsistent back-pressure from particle contamination triggers system shutdowns and aborts analytical runs.
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Pump & Detector Damage
Abrasive particles wear pump pistons, seals, and check valves — leading to costly repairs and instrument downtime.
Sample-to-Injection Flow: What Can Go Wrong
Chromatography Filtration Products
Precision-engineered filtration solutions designed specifically for demanding chromatography workflows.
Syringe Filters
Ultra-low extractable syringe filters for HPLC, UHPLC, and LC-MS sample preparation. Available in PVDF, Nylon, PTFE, MCE and Cellulose Acetate membranes.
- Ultra-low extractables — minimal interference
- Precise pore structure (0.20µm, 0.22µm, 0.45µm)
- Clog-resistant with glass fiber pre-filter
- High chemical compatibility with solvents
- Available in 4mm, 13mm, 25mm, 33mm diameters
Membrane Disc Filters
High-throughput membrane disc filters for mobile phase filtration and sample clarification. Ideal for vacuum filtration systems used in HPLC mobile phase prep.
- High flow rate — low differential pressure
- Low pressure drop for rapid throughput
- Compatible with vacuum filtration systems
- Broad chemical resistance (aqueous & organic)
- Available 25mm, 47mm, 50mm, 90mm, 142mm
Who Uses Dorsan Filtration Products?
From pharmaceutical QC to academic research — our filters are validated for demanding analytical environments across sectors.
Pharmaceutical QC Labs
API testing, finished product analysis, dissolution media filtration, and stability studies demand the highest-purity filtration. Dorsan’s low-extractable membranes are compliant with ICH and USP guidelines.
Bioanalytical & CRO Labs
LC-MS/MS quantitation of drugs in plasma, urine, and tissue requires ultra-low background. PVDF and PTFE filters with documented extractable profiles protect your mass spec signal integrity.
University & Research Labs
Academic researchers need reliable, cost-effective filtration for natural product analysis, metabolomics, proteomics, and environmental chemistry. Bulk pricing and COA documentation available.
Food & Beverage Testing
Pesticide residue analysis, mycotoxin detection, and adulteration testing in complex food matrices require clog-resistant filters with broad chemical compatibility and high particle loads.
Environmental & Water Testing
Ground water, effluent, and drinking water analysis demands high-throughput membrane disc filters. Dorsan’s vacuum filtration discs handle high-turbidity samples with minimal clogging.
Clinical & Diagnostic Labs
Therapeutic drug monitoring and clinical biomarker analysis using HPLC-UV and LC-MS requires consistent, sterile-grade filtration with documented biocompatibility for biological matrices.
Recommended Chromatography Filtration Workflow
Follow this validated workflow for consistent, reliable HPLC and LC-MS results every time.
Sample Preparation
Dissolve & dilute in appropriate solvent
Pre-Filtration
Remove large particles with pre-filter (5µm)
Syringe Filtration
0.22µm syringe filter before injection
Mobile Phase Filtration
Membrane disc filter for solvent prep
Degassing
Sonicate or use online degasser
HPLC Injection
Clean sample → reliable chromatogram
Why Choose Dorsan Filtration?
Built for analytical laboratories that demand precision, reliability, and consistent performance run after run.
Advanced Membrane Technology
Proprietary casting processes deliver membranes with tight pore size distribution for precise, reproducible filtration at analytical scale.
Global Manufacturing Standards
Manufactured in ISO-certified facilities with stringent QC protocols — every batch tested before dispatch to your laboratory.
High Chemical Compatibility
Extensive membrane material range — PVDF, Nylon, PTFE, MCE, PES — compatible with aqueous buffers, organic solvents, and aggressive acids/bases.
Consistent Quality Control
100% bubble-point tested membranes with documented lot-to-lot consistency. Certificate of Analysis available for every batch.
Designed for Chromatography Labs
Every design decision optimized for HPLC workflows — from housing geometry that minimizes dead volume to membranes that produce the lowest extractable profiles.
Trusted by Research Institutions
Used in pharmaceutical QC labs, universities, contract research organizations, and government analytical laboratories across India and beyond.
Which Membrane is Right for Your Application?
Use this quick reference table to select the correct membrane material for your HPLC, UHPLC, or LC-MS workflow.
| Membrane | Best For | Aqueous | Organic Solvents | Strong Acids/Bases | LC-MS Grade | Protein Binding | Recommended For |
|---|---|---|---|---|---|---|---|
| PVDF Most Popular | HPLC, LC-MS, Protein samples | ✓ | ✓ | Partial | LC-MS Grade | Low | Pharmaceutical QC, Bioanalytical |
| Nylon (PA) | Aqueous buffers, mild organic | ✓ | ✓ | ✗ | Standard | Moderate | Mobile phase prep, General HPLC |
| PTFE Solvent Resistant | Aggressive solvents, strong acids | With wetting | ✓ | ✓ | LC-MS Grade | Very Low | Strong acid/base matrices, Non-aqueous HPLC |
| MCE (Mixed Cellulose) | Aqueous samples, low protein binding | ✓ | ✗ | ✗ | Standard | Very Low | Water testing, Aqueous buffers |
| PES (Polyethersulfone) | Biological fluids, cell culture | ✓ | Limited | ✗ | Standard | Very Low | Proteins, Enzymes, Biologics |
| Cellulose Acetate (CA) | Aqueous, low-protein binding needed | ✓ | Limited | ✗ | Standard | Low | Clinical samples, Diagnostics |
How to Get Your Free Product Samples
We make it easy to evaluate Dorsan filtration products in your own laboratory before committing to a bulk order. Here’s exactly what to expect:
Submit Your Sample Request
Fill in the short form on this page with your name, lab details, product interest, and application. Takes less than 2 minutes.
Technical Review & Sample Pack Selection
Our technical team reviews your application and selects the ideal membrane type, pore size, and filter format for your specific workflow.
Sample Dispatch — Pan-India Delivery
Your sample pack is dispatched from our Ahmedabad warehouse with a Certificate of Analysis and product data sheet included.
Evaluate in Your Lab & Place Order
Test in your real workflow. Our team follows up to answer any questions, share application notes, and process your bulk order when you’re ready.
What’s Included in Your Sample Pack
Every sample request is fulfilled with a curated selection based on your application.
What Analytical Scientists Say
Reliable filtration performance across our entire HPLC workflow. The PVDF syringe filters show extremely low extractables even with complex pharmaceutical matrices — we’ve had zero ghost peak issues since switching to Dorsan.
We tested three brands of membrane disc filters for our LC-MS mobile phase prep. Dorsan’s 0.22µm PVDF discs consistently delivered the cleanest baselines and highest flow rates. The sample-to-sample reproducibility is outstanding.
Column lifetime has increased significantly since we standardized on Dorsan syringe filters. The technical team was helpful in recommending the right membrane for our acetonitrile-heavy gradient system. Fast delivery and good stock availability.
Our university research lab runs 50–80 HPLC injections daily. Dorsan Nylon filters are cost-effective and perform consistently for aqueous buffer systems. Technical documentation is clear and the Certificate of Analysis is always provided.
Certifications & Standards
ISO 9001:2015
International quality management system certification
GMP Compliant
Good Manufacturing Practice for pharmaceutical-grade production
GLP Compatible
Good Laboratory Practice — suitable for regulated analytical environments
REACH Compliant
European Union chemical safety and registration standard
Frequently Asked Questions
Everything you need to know about our filtration products for chromatography applications.
Request Chromatography Filtration Product Samples
Fill out the form below and our technical team will contact you within 24 hours with sample dispatch details.
Improve Chromatography Results with Reliable Filtration
Join 500+ laboratories across India using Dorsan filtration solutions for HPLC, UHPLC, and LC-MS workflows.